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Lailai Yan

10 representative papers

Education Background

08/2011-to present  Research Assistant: Department of Laboratorial Science and Technology, School of Public Health, Peking University, Beijing, P. R. China

09/2009-08/2011  Junior Research Fellow: Department of Laboratorial Science and Technology, School of Public Health, Peking University, Beijing, P. R. China

09/2012-01/2017   Doctor, School of Public Health, Peking University, Beijing, P.R. China

09/2006-07/2009   Master, School of Public Health, Peking University, Beijing, P.R. China

09/2001-07/2006   Bachelor, School of Public Health, Shanxi Medical University, Shanxi, P.R. China

Overall introduction

My main interest is to adopt multidisciplinary study methods such as Sanitary Chemistry, epidemiology, clinical medicine, and bioinformatics to elucidate the association of metals exposure with human health and the potential mechanism by analyzing the content of metals in biological samples. I have participated in two national key research and development projects as backbone member,and in the National Natural Science Foundation-Regional Science Foundation project as a partner. As the first or corresponding author, I have published more than 20 papers in international authoritative journals, e.g., Journal of hazard materials、Environment International、Science of the total environment、 Environmental Pollution. I served as a member of the Atomic Spectrometry Application and Technology Committee, and the Deputy Secretary General of Beijing Metallomics platform. I has participated in the teaching of Scientific Instrument Experimental Skills, Advanced Medical and Health Instrument Analysis, Advanced Medical Technology and Problem-Based Learning experimental teaching in the school of public health. In 2020, I won the second prize of the 20th Peking University Young Teachers' basic teaching skills competition (medical category) and the first prize at the school of public health.

Main research directions

Relationship between metallomics and human health, Application of instrument analysis in the field of public health

Representative scientific research projects

  1. National Key Research and Development Program: Assessment and Application Demonstration of the Air Pollution Health Effect in Typical Areas, 2023YFC3708305, Sub-project Ⅳ: "Research on the Tracing the Whole Chain of the Causes in Air Pollution induced Diseases and Evaluating the Disease Burden", Principal Investigator of Sub-project II, 2023/12-2027/11, 890,000 RMB, Principal Investigator, Ongoing.

  2. National Key Research and Development Program: Intergovernmental International Cooperation on Science, Technology and Innovation (China and the United States), Exposure characteristics of typical emerging agrochemicals and their reproductive health risk assessment, 2022YFE0134900, Sub-projectI: "Exposure characteristics of typical emerging agrochemicals and their correlation with reproductive health effects", Principal Investigator of Sub-project I, 2023/01-2025/12, 200,000 RMB, Principal Investigator, Ongoing.

  3. National Natural Science Foundation of China (NSFC)-Regional Science Foundation project, 82060600, The correlation study of Baiyun obo mine area light rare earth elements exposure and small for gestational age, 2021/01-2024/12, 401, 000 RMB, Partner, Ongoing.

  4. The interdisciplinary medicine Seed Fund of Peking University, BMU2017MX006, Research on first-episode schizophrenia based on metallomics and amino acid metabolomics in plasma, 2018/01-2018/12,Principal Investigator, Completed.

10 representative papers

  1. Minghao Wang#, Lailai Yan#, Siqi Dou#, Liu Yang, Yiwen Zhang, Wenzhong Huang, Shanshan Li, Peng Lu*, Yuming Guo*, Blood multiple heavy metals exposure and lung function in young adults: A prospective Cohort study in China, Journal of Hazardous Materials,459(2023)132064.

  2. Bing Cao#*, Ruiqi Wang#, Angela T.H. Kwan, Roger S. McIntyre , Lailai Yan* Association between rare earth elements and depression: Evidence from pilot mice model of chronic unpredictable mild stress-induced depression and human studies of major depressive disorder, Chemosphere, 345 (2023) 140525.

  3. Weiling Han , Wei Zheng , AiliWang , Junxi Chen , JiaWang, Junhua Huang, Hang An Yuru Ma, Kexin Zhang, Ruihua Yang, Lailai Yan*, Zhiwen Li and Guanghui Li* Association of Maternal Plasma Manganese with the Risk of Spontaneous Preterm Birth: A Nested Case–Control Study Based on the Beijing Birth Cohort Study (BBCS) in China, Nutrients, 2023,15(6),1413.

  4. Gongbo Chen#, Jiping Tan#, Lailai Yan#, Nan Li, Luning Wang, Na Li, Lei Mai, Yiming Zhao, Shanshan Li,Yuming Guo Long-term exposures to ambient PM1 and NO2 pollution in relation to mild cognitive impairment of male veterans in China. Environmental Research Letters,2021,16(2),025013

  5. Mengyuan Ren#, Lailai Yan#, Yiming Pang, Xiaoqian Jia, Jing Huang , Guofeng Shen, Hefa Cheng, Xilong Wang, Bo Pan, Zhiwen Li, Bin Wang. External interference from ambient air pollution on using hair metal(loid)s for biomarker-based exposure assessment. Environment International, 2020,137,105584.

  6. Yongxiu Hao#, Lailai Yan#, Yiming Pang, Huina Yan, Le Zhang, Jufen Liu, Nan Li, Bin Wang, Yali Zhang* , Zhiwen Li, Rongwei Ye, Aiguo Ren. Maternal serum level of manganese, single nucleotide polymorphisms, and risk of spontaneous preterm birth: A nested case-control study in China. Environmental Pollution, 2020,262,114187.

  7. Yiming Pang#, Lailai Yan#, Mengyuan Ren, Xiaoqian Jia, Tanxin Liu, Wei Du, Bin Wang , Zhiwen Li*, Qun Lu*. Environmental complex exposure and the risk of influenza-like illness among housewives: A case study in Shanxi Province, China. Ecotoxicol Environ Saf.2020, 194:110405.

  8. Bing Cao, Yan Chen, Joshua D. Rosenbalt, Roger S. McIntyre, Dongliang Wang*, Lailai Yan*. Association of alkali metals and Alkaline-earth metals with the risk of schizophrenia in a Chinese population: A Case-Control study. Journal of Trace Elements in Medicine and Biology, 2020,60: 126478.

  9. Lailai Yan#, Juntuo Zhou#, Dong fang Wang, Dan dan Si,Ya qiong Liu,Li jun Zhong* Yuxin Yin*. Unbiased lipidomic profiling reveals metabolomic changes during the onset and antipsychotics treatment of schizophrenia disease, Metabolomics, 2018, 14(6):80.

  10. Lailai Yan#, Bin Wang#, Zhenjiang Li, Yaqiong Liu, Wenhua Huo, Jingyu Wang*, Zhiwen Li*, Aiguo Ren, Association of essential trace metals in maternal hair with the risk of neural tube defects in offspring, Birth Defects Research A, 2017, 109(3): 234-243.

Note:*Corresponding author, #Co-first author