Linlin Wang-Linlin Wang-PKU Institute of Reproductive & Child Health

Education Background

08/2018-to present Researcher: Institute of Reproductive and Child Health Department of Epidemiology and Health Statistics, School of Public Health, Peking University, Beijing, P. R. China
08/2012-07/2018 Assistant Researcher: Institute of Reproductive and Child Health Department of Epidemiology and Health Statistics, School of Public Health, Peking University, Beijing, P. R. China
07/2012-08/2012 Visiting scholar: Department of Nutritional Sciences, University of Texas at Austin, Austin, TX, USA
04/2009-07/2012 Lecturer: Institute of Reproductive and Child Health Department of Epidemiology and Health Statistics, School of Public Health, Peking University, Beijing, P. R. China
07/2010-08/2010 Visiting scholar: The Nutrition Laboratory, Centers for Disease Control and Prevention, Atlanta, GA, USA
02/2010-03/2010 Visiting scholar: Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, TX, USA
09/2005-03/2009 PhD, School of Public Health, Peking University, Beijing, P. R. China

Overall introduction

Dr. Wang has been engaged in the exploration and application of the causes and mechanisms behind reproductive health and birth defects. Her studies provide novel scientific evidence for the causes and mechanisms of major birth defects, supports population prevention strategies, and have achieved a series of achievements. As a principal investigator, she has funded by more than 10 national projects, including the Major Program of National Social Science Foundation of China, the National Key Research and Development Program of China, the National Natural Science Foundation of China, the Beijing Municipal Natural Science Foundation, etc. She has also participated in several international projects funded by the National Institutes of Health in the United States. As the first or corresponding author, she has published more than 70 papers, including Environ Sci Technol, Journal of Hazardous Materials, Sci Total Environ, Chemosphere, Environmental Research, Epidemiology, Clin Epigenetics, Hum Genet, Br J Nutr, etc. She has awarded the Huang Tingfang/Xinhe Young Distinguished Scholar Fellowship, Beijing Science and Technology Award, Science and Technology Award of the Beijing Preventive Medicine, Chinese Medical Science and Technology Award, Scientific Research Achievement Award of the Ministry of Education, Science and Technology Award of the Chinese Preventive Medicine, etc.

Main research directions

Reproductive Health, Molecular Epidemiology, and Precision Nutrition

Representative scientific research projects

(1)	National Key Research and Development Program, 2022YFC2705205, Early diagnosis and intervention for early warning on common developmental and behavioral disorders in children, 2022/12-2025/11，Principal Investigator, Ongoing.
(2)	Major Program of National Social Science Foundation of China, 21&ZD187, Prevention strategies and application of developmental disability in the context of population aging population aging, 2021/12-2024/12, Principal Investigator, Ongoing.
(3)	National Key Research and Development Program, 2021YFC2701101, Systematic identification of pathogenic mutations of major birth defects, 2021/12-2024/11, Co-Investigator, Ongoing.
(4)	Horizontal collaboration project, Study on breast milk composition based on birth cohort, 2019/11-2025/03, Principal Investigator, Ongoing.
(5)	National Natural Science Foundation of China General Program, 81773441, Somatic mutation in fetal central nervous tissue and neural tube defects, 2018/01-2021/12, Principal Investigator, Completed.
(6)	National Key Research and Development Program, 2016YFC1000501, critical phase of environmental factors lead to vital organs abnormal development, 2016/07-2021/06, Co-Investigator, Completed.
(7)	Beijing Municipal Natural Science Foundation, 7162094, Aberrant DNA methylation of homeobox genes and neural tube defects, Principal Investigator, Completed.
(8)	National Natural Science Foundation of China General Program, 81472987, Association of rare variants and aberrant DNA methylation in PCP pathway with anencephaly, 2015/01-2018/12, Principal Investigator, Completed.
(9)	National Natural Science Foundation of China Young Scientist Fund, 81202215, Association between maternal autoantibodies to folate receptors and the risk of neural tube defects, 2013/01-2015/12, Principal Investigator, Completed.
(10)	Fund for Doctor Station, 20100001120132, Ministry of Education, Association between maternal or fetal autoantibodies to folate receptor and folate levels, 2011/01-2013/12, Principal Investigator, Completed.

10 representative papers

(1)	Li, S., Wang, C., Yang, C., Chen, Y., Cheng, Q., Liu, J., Zhang, Y., Jin, L., Li, Z., Ren, A., Wang LL*. Prenatal Exposure to Poly/Perfluoroalkyl Substances and Risk for Congenital Heart Disease in Offspring. Journal of Hazardous Materials, 2024, 469: 134008.
(2)	Zhu, H., Cheng, Q., Liu, J., Jin, L., Li, Z., Ren, A., Wang LL*. Associations among bisphenol A, its analogs, and chlorinated derivatives in placenta and risk for neural tube defects: A case-control study. Sci Total Environ, 2023, 900: 165586.
(3)	Yang, C., Guo, Q., Cui, M., Li, X., Zhang, J., Peng, X., Liu, J., Liu, P. , Wang LL**. Association between maternal metabolic profiles in pregnancy, dietary patterns during lactation and breast milk leptin: a retrospective cohort study. Br J Nutr, 2023, 130(9): 1537-1547.
(4)	Wang C., Pi X., Chen Y., Wang D., Yin S., Jin L., Li Z., Ren A, Wang LL*. and Yin C. Prenatal exposure to barium and the occurrence of neural tube defects in offspring. Sci Total Environ. 2021;764:144245.
(5)	Liu L, Guo Q, Liu P, Wang LL**. Impact of maternal albumin and hemoglobin during early pregnancy and diet during lactation on lactoferrin in mature human milk. Nutrition. 2022;93:111500.
(6)	Tian T, Lei YP, Chen YY, Karki M, Jin L, Finnell RH, Wang LL, Ren AG. Somatic mutations in planar cell polarity genes in neural tissue from human fetuses with neural tube defects. Hum Genet. 2020;139(10):1299-314.
(7)	Yang W, Ni W, Jin L, Liu J, Li Z, Wang LL*, Ren A. Determination of organochlorine pesticides in human umbilical cord and association with orofacial clefts in offspring. Chemosphere. 2020; 266:129188.
(8)	Chen Y, Liu L, Ni W, Jin L, Li Z, Ren A, Wang LL*. Association between selected alkaline earth elements concentrations in umbilical cord and risk for cleft lip with or without cleft palate. Sci Total Environ 2020; 750:141735.
(9)	Huang Y, Ren A, Wang LL**, Jin L, Lin S, Li Z, McDonald JA. Casp8 hypomethylation and neural tube defects in association with polycyclic aromatic hydrocarbon exposure. Clin Epigenetics 2019;11(1):72.
(10)	Ni W, Yang W, Yu J, Li Z, Jin L, Liu J, Zhang Y, Wang LL*, Ren A. Umbilical Cord Concentrations of Selected Heavy Metals and Risk for Orofacial Clefts. Environmental Science & Technology 2018; 52:10787-95.