Lei Jin

Title：Associate Professor, Doctoral Supervisor

Major: Epidemiology and Biostatistics

E-mail：Jin_lei@pku.edu.cn

Address：38 Xueyuan Rd , Haidian District,Beijing,China

Personal profile

09/2015-to present Associate Professor: School of Public Health, Peking University, Beijing, P. R. China.

03/2015~08/2015 Visiting scholar: Humboldt-University, Berlin, Germany.

02/2011~02/2015 Associate Professor: School of Public Health, Peking University, Beijing, P. R. China.

10/2004~01/2007 Postdoc: Peking Union Medical University, Chinese Academy of Medical Sciences, Beijing, P. R. China.

01/2002~09/2004 Associate Professor: Medical College, Shi He Zi University, Xinjiang, P. R. China.

09/1998~12/2001 PhD, School of Public Health, Peking University, Beijing, P.R. China

07/1994~08/1998 Lecture: Medical College, Shi He Zi University, Xinjiang, P. R. China.

09/1991~07/1994 Graduate student: School of Public Health, Fudan University, Shanghai, P. R. China.

07/1989~08/1991 Assistant: Medical College, Shi He Zi University, Xinjiang, P. R. China.

09/1984~07/1989 BE, Medical College, Shi He Zi University, Xinjiang, P. R. China.

Overall introduction

I’m focusing on epidemiological research on reproductive health for over 30 years, and have published 187 academic papers in core journals in Chinese or English, including 60 as first author or corresponding author (32 SCI indexed journals and 28 in Chinese). I have discovered that maternal exposure to mercury would increase the risk of fetal neural tube defects; and evaluated the effectiveness of the implementation of the national public health program "Population folic acid supplementation to prevent neural tube defects" on major birth defects such as neural tube defects, as well as premature birth and intrauterine growth retardation, and reported a spatiotemporal developmental atlas of human brain development covering multiple time points between GW6 and GW23 as well as multiple brain regions collaborating with other disciplines. I teach the undergraduate course "Environment and Child Health" and the postgraduate course "Reproductive and Perinatal Epidemiology”. I serve as an editorial board member of the Chinese Journal of Reproductive Health, a reviewer for a few SCI indexed journals, an executive member of the Environment and Reproductive Health Special Committee of the Chinese Association of Eugenics, a member of the Birth Defects Prevention and Molecular Genetics Branch of the Chinese Maternal and Child Health Association, and a member of the Environment and Health Branch of the Chinese Society of Environmental Sciences. I received the second prize in science and technology from the Beijing Preventive Medicine Association and the third prize in Huaxia Medical Science and Technology Award.

Main research directions

Epidemiology on reproductive and child health; Environment and reproductive health; Birth defect prevention

Representative scientific research projects

(1) National Social Science Foundation, Major Project: Prevention strategies and applications of developmental disabilities in the context of population aging”, 12/2021-12/2024, key investigator.

(2) National Key Research and Development Program: The impact and mechanisms of changes of environmental and epigenetic on structure birth defects”, 12/2021-11/2024, key investigator.

(3) National Key Research and Development Program: Screening and mechanism of maternal and fetal metabolism of glucose and lipid biomarkers, 12/2021-11/2024, key investigator.

(4) The Health Bureau of the Logistics Support Department of the Military Commission, key project: Establishment of a quantitative scoring system for pernicious placenta previa and construction of the special treatment center in military, 07/2020–06/2024, key investigator.

(5) Capital Health Development Scientific Research Funding, key project: The relationship between maternal folic acid supplementation in early pregnancy and risk of gestational diabetes, 01/2020–06/2023, key investigator.

(6) National Key Research and Development Program: Cohort study of the effects of environmental and behavioral factors on embryonic development and maternal health based on external exposure surveillance, 12/2018–12/2021, key investigator.

(7) National Key Research and Development Program: Environmental determinants of major birth defects, 07/2016–06/2021, key Investigator.

10 representative papers

(1) Li Y, Li Z, Wang C, Yang M, He Z, Wang F, Zhang Y, Li R, Gong Y, Wang B, Fan B, Wang C, Chen L, Li H, Shi P, Wang N, Wei Z, Wang YL, Jin L*, Du P*, Dong J*, Jiao J*. Spatiotemporal transcriptome atlas reveals the regional specification of the developing human brain. Cell, 2023, 186, 5892–5909.

(2) Yin SJ, Sun Y, Yu JH, Su ZM, Tong MK, Zhang YL, Liu JF, Wang LL, Li ZW, Ren AG*, Jin L*. A High Concentration of Polycyclic Aromatic Hydrocarbons in Umbilical Cord Tissue is Associated with an Increased Risk for Fetal Neural Tube Defects. Expos Health, 2022, Doi: 10.1007/s12403-022-00476-2.[]

(3) Wang D, Jin L, Zhang J, Meng W, Ren A, Jin L*. Maternal Periconceptional Folic Acid Supplementation and Risk for Fetal Congenital Heart Defects. The Journal of pediatrics, 2022, 240:72-8. Doi: 10.1016/j.jpeds.2021.09.004.

(4) Li Y, Li Z, Yang M, Wang F, Zhang Y, Li R, Li Q, Gong Y, Wang B, Fan B, Wang C, Chen L, Li H, Ong J, Teng Z, Jin L*, Wang YL*, Du P*, Jiao J*. Decoding the temporal and regional specification of microglia in the developing human brain. Cell Stem Cell, 2022, 29(7): 620-34. Doi: 10.1016/j.stem.2022.02.004.

(5) Zhang J, Jin L, Wang D, Wang C, Tong M, Yu J, Meng W, Ren A, Jin L*. Maternal periconceptional folic acid supplements use and fetus risk for limb defects. Paediatric and perinatal epidemiology, 2021, 35(6): 645-53. Doi: 10.1111/ppe.12775.

(6) Yin S, Sun Y, Yu J, Su Z, Tong M, Zhang Y, Liu J, Wang L, Li Z, Ren A*, Jin L*. Prenatal exposure to organochlorine pesticides is associated with increased risk for neural tube defects The Science of the total environment, 2021, 770:145284. Doi: 10.1016/j.scitotenv.2021.145284.

(7) Tong M, Yu J, Liu M, Li Z, Wang L, Yin C, Ren A, Chen L*, Jin L*. Total mercury concentration in placental tissue, a good biomarker of prenatal mercury exposure, is associated with risk for neural tube defects in offspring. Environment international, 2021, 150:106425. Doi: 10.1016/j.envint.2021.106425.

(8) Liu M, Wang D, Wang C, Yin S, Pi X, Li Z, Wang L, Liu J, Yin C, Jin L*, Ren A*. High concentrations of aluminum in maternal serum and placental tissue are associated with increased risk for fetal neural tube defects [J]. Chemosphere 2021, Doi: https://doi.org/10.1016/j.chemosphere.2021.131387.

(9) Wang B#, Jin L#, Ren A, Yuan Y, Liu J, Li Z, Zhang L, Yi D, Wang LL, Zhang Y, Wang X, Tao S, Finnell RH. Levels of polycyclic aromatic hydrocarbons in maternal serum and risk of neural tube defects in offspring [J]. Environmental science & technology, 2015, 49(1): 588-96. Doi: 10.1021/es503990v.

(10) Jin L, Liu J, Ye B, Ren A*. Concentrations of selected heavy metals in maternal blood and associated factors in rural areas in Shanxi Province, China [J]. Environment international, 2014, 66(157-64. Doi: 10.1016/j.envint.2014.01.016.

Future work

(1) To explore the environmental, genetic, and metabolic factors associated with maternal and child health, and their potential mechanisms, based on the mother child cohort in Beijing and animal experiment.

(2) To investigate the molecular mechanisms underlying the increased risk of neural tube defects caused by maternal exposure to heavy metals such as mercury and manganese during pregnancy.

(3) To investigate the mechanisms of maternal organic pollutants exposure and fetal high risk of congenital heart defects.